What is the difference between povidone and crospovidone

In general, crosslinked polyvinyl-pyrrolidone PVP grades show a limited swelling behavior to a certain particle volume, whereas Ac-Di-Sol and Primojel have more or less unlimited swelling and form a gel.

It is also noteworthy that neither swelling pressure nor volume expansion alone can explain the disintegration efficacy of excipients 3. Swelling of disintegrant particles is perhaps the most widely accepted mechanism for tablet disintegration, primarily because almost all disintegrants swell to some extent. To determine swelling volume in water, 10 g of polymers were weighed into a mL graduated cylinder.

The graduated cylinder was filled with water, closed, and shaken very well. The sediment volume was determined after 24 h. Kollidon CL-F has similar swelling volume to Polyplasdone.

Ac-Di-Sol and Primojel have the highest swelling volume. Because of its low bulk density 0. To determine the hydration capacity, 2 g of polymer were weighed into a centrifuge vessel with 40 mL of water. The polymer swelled for 15 min, and the suspension was centrifuged at rpm for 15 min. The supernatant was poured off, and the residual weight was determined. Crospovidone is one of the three superdisintegrants described in the literature.

The mechanism of action is a capillary action with a secondary swelling effect. The improvement of tablet disintegration also has been observed through predictable swelling without gel formation. Furthermore, swelling properties paired with particle-size distribution make the finer grades of crospovidone work efficiently in fast-disintegrating formulations.

The following formulations were tested to determine the disintegration properties:. Formulation 1. Formulation 1 consisted of Improve this answer. Sign up or log in Sign up using Google. Sign up using Facebook.

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After the s and s contact times, PVP-I oral antiseptic rinse at all 3 concentrations of 0. The H2 O2 solutions at concentrations of 1. Povidone-Iodine 0. Isotonic saline 0. Challenges, outlook, and future perspectives In the current scrutiny, synthesis, grades, properties, and applications of PVP as a pharmaceutical excipient are discussed. Conclusion Based on the current literature survey, PVP is considered a widely used excipient for pharmaceutical, food, and cosmetic industry.

Funding None. Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. References 1. Haaf F. Polymers of n-vinylpyrrolidone: synthesis, characterization and uses. Koczkur K. Polyvinylpyrrolidone PVP in nanoparticle synthesis. Kurakula Mallesh, Koteswara Rao G. Moving polyvinyl pyrrolidone electrospun nanofibers and bioprinted scaffolds toward multidisciplinary biomedical applications.

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